During Disney’s 3-D panel at Comic-Con, director Robert Zemekis — who was on hand to present his upcoming 3-D motion-capture film A Christmas Carol — was asked if there was any truth in the rumors about a sequel to Who Framed Roger Rabbit?. Zemeckis dodged the question, saying that he could “neither confirm or deny”, but that wasn’t good enough for the audience who forced Zemeckis to reveal a bit more on the topic:
“I will tell you this, if that ever does happen, the 2D characters from the original movie will remain 2D. They will not be dimensionalized. Not to say there wont be 3D [in the movie].”
Sounds to me like this is definitely a possibility.