Edward Norton, star of The Incredible Hulk, talked to Total Film magazine and said that there will be no connection to the 2003 film Hulk.
From the interview (via The Sun):
“First off it’s utterly unrelated to that film,” he said, in this month’s Total Film magazine.
“This is in no way a response to it or picking up from it.
“I think like Chris Nolan and those guys did with Batman, we just said: ‘We’re going to start completely with our own version of this myth or saga.’